Ion Mobility-Mass Spectrometry in the Omics

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Событие: Ion Mobility-Mass Spectrometry in the Omics

в Конференции, выставки и семинары
Кем добавлено Vadim Sharov , 24 Июл 2019


Время проведения 16 Окт 2019 (Событие на один день)

View Discussion Topic    Vadim Sharov



Christopher Chouinard, PhD


Assistant Professor of Chemistry, Department of Biomedical and Chemical Engineering and Sciences (BCES), Florida Institute of Technology



DATE: October 16, 2019

 


Ion mobility-mass spectrometry (IM/MS) is a rapid, gas-phase separation technique that has become an integral part of the analytical repertoire of techniques for -omics. This method couples well with existing protocols (i.e., LC/MS) by affording an additional dimension of separation, and provides a characteristic measure of an analyte’s size, shape, and charge in the form of a collision cross section (CCS). CCS can be used to increase confidence in quantitative measurement of known compounds, thus reducing interferences and improving S:N ratios, and, also serves as a defining feature in identification of unknowns. Furthermore, this separation based on structure (as opposed to mass-to-charge alone) allows for distinction of structural and stereoisomers of potential biological importance. This presentation will cover the basic operating principles of IMS and current instrumentation; applications to metabolomics, lipidomics, and proteomics; and future directions for IM/MS.

 

Learning Objectives:

  • Understand the basic operating principles of IMS and current instrumentation
  • Understand current applications to metabolomics, lipidomics, and proteomics

https://www.labroots...rometry-omics-2




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